Understanding of interaction (subgroup) analysis in clinical trials
نویسندگان
چکیده
منابع مشابه
Analysis of Subgroup Data of Clinical Trials
Large randomized controlled clinical trials are the gold standard to evaluate and compare the effects of treatments. It is common practice for investigators to explore and even attempt to compare treatments, beyond the first round of primary analyses, for various subsets of the study populations based on scientific or clinical interests to take advantage of the potentially rich information cont...
متن کاملEBM: TRIALS ON TRIAL Subgroup analysis in clinical trials
Department of Physiology, University of Sydney, Sydney, NSW. David I Cook, MD, FRACP, Professor of Cellular Physiology. NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW. Val J Gebski, BA, MStat, Associate Professor and Principal Research Fellow; Anthony C Keech, MScEpid, FRACP, Deputy Director. Reprints will not be available from the authors. Correspondence: Professor David I...
متن کاملConsiderations on Subgroup Analyses in Clinical Trials.
As clinicians, we routinely treat patients with drugs whose efficacy is supported by evidence from multicenter clinical trials, some of which include thousands of patients from different parts of the world. When it comes to treating a given patient, however, we need to know whether the beneficial effect described for the average patient will apply to this patient in particular. This can be done...
متن کاملAdaptively Changing Subgroup Proportions in Clinical Trials
During the course of a fixed sample size clinical trial, differences in the size of the treatment effect between strata may become pronounced. If rejecting the null hypothesis of no treatment effect is of paramount concern, it may make sense to increase representation of the more responsive stratum to increase power of the trial. Additionally, strata in which treatment is harmful may need to be...
متن کاملanalyzing patterns of classroom interaction in efl classrooms in iran
با به کار گیری روش گفتما ن شنا سی در تحقیق حا ضر گفتا ر میا ن آموزگا را ن و زبا ن آموزا ن در کلا سهای زبا ن انگلیسی در ایرا ن مورد بررسی قرار گرفت. ا هداف تحقیق عبا رت بودند از: الف) شنا سا ئی سا ختارهای ارتبا ط گفتا ری میا ن معلمین و زبا ن آموزا ن ب) بررسی تا ثیر نقش جنسیت دبیرا ن و زبا ن آموزان بر سا ختا رهای ارتبا ط گفتا ری میا ن آنها پ) مشخص کردن اینکه آ یا آموزگاران غا لب بر این ارتبا ط گف...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Clinical Investigation
سال: 2019
ISSN: 0014-2972,1365-2362
DOI: 10.1111/eci.13145